Asro Medika

Rabu, 04 Januari 2012

Nitroglycerin and Nitrates for Patients with Ischemic Heart Disease

 Nitroglycerin and Nitrates for Patients with Ischemic Heart Disease
Compound Route Dose Duration of Effect
Nitroglycerin Sublingual tablets 0.3–0.6 mg up to 1.5 mg Approximately 10 min
Spray 0.4 mg as needed Similar to sublingual tablets
Ointment
2% 6 x 6 in; 15 x 15 cm
7.5-40 mg
Effect up to 7 h
Transdermal 0.2–0.8 mg/h every 12 h 8–12 h during intermittent therapy
Oral sustained release 2.5–13 mg 4–8 h
Intravenous 5–200 g/min Tolerance may be seen in 7–8 h
Isosorbide dinitrate Sublingual 2.5–10 mg Up to 60 min
Oral 5–80 mg, 2–3 times daily Up to 8 h
Spray 1.25 mg daily 2–3 min
Chewable 5 mg 2–2½ h
Oral slow release 40 mg 1–2 daily Up to 8 h
Intravenous 1.25–5.0 mg/h Tolerance in 7–8 h
Ointment 100 mg/24 h Not effective
Isosorbide mononitrate Oral 20 mg twice daily60–240 mg once daily 12–24 h
Pentaerythritol tetranitrate Sublingual 10 mg as needed Not known

Source: Modified from RJ Gibbons et al.

Tidak ada komentar:

Posting Komentar